9j/81vTP/Yr/ANTJKV9j/wDNb0z/ANiv/UySlfY//Nb0z/2K/wDUySlfY/8AzW9M/wDYr/1MkpX2 Adobe InDesign 7.5 tySGu5qxh6TY/wCMk2T5hzfgkpPj4WJiAjGqZXuMvIHucfFzuXHzKSmdmPTbq9gmCA4e1wDtDDmw xmp.iid:5ABA62FD5399E2119707FABFF5326004 The failure of this safety mechanism will lead to cardiac asystole and death. 2012-04-02T11:41:47+05:30 xmp.iid:292647274477E111B4F3A678B07F6151 22//AMikpX/PT6vf9yHf9tv/APIpKV/z0+r3/ch3/bb/APyKSnQ6b1bB6vW+3BebG1u2uJaW6xP5 2012-03-26T21:23:59+05:30 /;/metadata Increased excitability of the myocardium causing propagation of ectopics. On complete autopsy, including toxicology and microscopy, no abnormalities are noted. JSv+bN3/AJY3f9t1f+QSUmxOgOxshl1uW/IY2ZqsrrDXSCNYaDpMpKdH7Ji/6Gv/ADB/ckpX2TF/ <>stream 2013-05-24T22:12:31+05:30 Adobe InDesign 7.5

saved saved Cases with patients who died suddenly, unexpected and unexplained due to suspected or confirmed cardiac disease were consecutively referred to our third line referral center, Rigshospitalet, Copenhagen University Hospital, Denmark for evaluation. Adobe InDesign 7.5 Adobe InDesign 7.5 Adobe InDesign 7.5 /cTpn/buZ/6USUr/AJnZ/wD3E6Z/27mf+lElK/5nZ/8A3E6Z/wBu5n/pRJTq431O6L6DPtmIz14/ /;/metadata /;/metadata The online-only Data Supplement is available at http://circep.ahajournals.org/lookup/suppl/doi:10.1161/CIRCEP.113.000111/-/DC1. xmp.iid:EFFBB8A9CEC7E21199FCB9B5C8636C76 endobj /wBx+jf+xZ/9KJKV6GJ/3H6N/wCxZ/8ASiSlehif9x+jf+xZ/wDSiSlehif9x+jf+xZ/9KJKV6GJ

Registered users can save articles, searches, and manage email alerts. lK3/APDdB/7a/wDUKSlb/wDhug/9tf8AqFJSt/8Aw3Qf+2v/AFCkpW//AIboP/bX/qFJSt//AA3Q hcAa+2czE7n8x5E/FJTifaL/AN5//uXp/wDJJKV9ov8A3n/+5en/AMkkpX2i/wDef/7l6f8AySSl

saved endobj Adobe InDesign 7.5 q0bmOgiQfJwBSUlSU1uoYY6hh2YjrH0izb+kqO142uDtD8klON/zNp/8sc3/ALcH/kUlOh0norOk Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. /;/metadata xmp.iid:F3B5A1025377E111B4F3A678B07F6151 Given the relative rarity of SCDs from inherited conditions and the challenges associated with their diagnosis, the authors propose that all cases of SCDs and, particularly, SCDs in young (≤35 years) individuals, where an inherited condition is suspected or diagnostic uncertainty remains as to the cause of death, should be referred for further evaluation to an expert cardiac pathologist. xmp.iid:82523E330BC1E2119474EC0BD1A471B9 xmp.iid:BFEFCAE7F097E211859C9FEA10FC5703 xmp.iid:2EE9ACF5A57CE1118961C8A22AFF80AA /;/metadata v3m/5p/8mkpUXfvN/wA0/wDk0lKi795v+af/ACaSlRd+83/NP/k0lKi795v+af8AyaSlRd+83/NP

SUt+wfrB/pen/wDsO3/0mkpX7B+sH+l6f/7Dt/8ASaSlfsH6wf6Xp/8A7Dt/9JpKd1nTcEMaH41B Virchows Arch. xmp.iid:BA177153DAC7E21199FCB9B5C8636C76 xmp.iid:E18E2717EE97E211859C9FEA10FC5703 saved saved xmp.iid:139D614ED597E211859C9FEA10FC5703 Adobe InDesign 7.5 2013-03-29T03:11:44+05:30 /;/metadata Adobe InDesign 7.5 2013-05-24T14:37:51+05:30 x�%̱�0����5z��#W�{�" !�3����b\���͢����,,�q,�� 2�0�o�}�CJ��1~�c�Ӓk|�Y��GҦ�p�a[�e��������D�� 2013-05-20T13:38:12+05:30 eJ/oK/8AMb/ckpX2PE/0Ff8AmN/uSUr7Hif6Cv8AzG/3JKV9jxP9BX/mN/uSUr7Hif6Cv/Mb/ckp saved <>>>/BBox[0 0 585 783]/Length 115>>stream xmp.iid:7E9985A243B9E11195148F4A8D42EC22

endobj SSlJKa/Tv+T8X/ia/wDqQkpWeXNwclzNwcKXluxgsdO0xtY6A4+XdJTxn2vqn7+b/wC4qj/0okpI x�+� � | Using both clinical and genetic evaluation of the family, if an underlying diagnosis is made, then subsequent management and follow-up depends on the disease in question, and will often trigger more specific family cascade clinical screening and, if available, genetic testing.26 If no diagnosis is made after comprehensive clinical (+/− genetic analysis), then asymptomatic adult relatives are generally followed up till age 40 years (by which time most genetic heart diseases have expressed phenotypically), and can be discharged from care on the proviso that new symptoms or family information should be reported immediately. Based on postmortem findings. Kong MH, Fonarow GC, Peterson ED, Curtis AB, Hernandez AF, Sanders GD, et al. /;/metadata 19 0 obj Low degrees myocardial inflammation was seen in 5 victims, but the degree of lymphocyte infiltration was deemed unlikely to be the cause of death. saved

2013-05-09T14:27:04+05:30 Until recently, the molecular autopsy has been confined to 4 targeted genes focused on the common causes of LQTS, BrS and CPVT. dJ6c8yZj7O6O/gEvbn2R72L978WXS+mdTb1LEc7EyABdWSTW8CA5uvCdjxyExos5jPjliIBd76/4 2013-03-30T22:15:36+05:30 xmp.iid:A51CBF15A904E311A91A9654266A8411 /wBx+jf+xZ/9KJKV6GJ/3H6N/wCxZ/8ASiSlehif9x+jf+xZ/wDSiSlehif9x+jf+xZ/9KJKV6GJ Adobe InDesign 7.5 All had electrocardiograms taken (n = 21, 100%), 11 (52%) had echocardiography, five (23%) had cardiac CT or MRI, four (19%) had coronary angiographies, four (19%) had Holter monitorings, and four (19%) had an exercise test performed. ih/5FJSv2fk/+V3U/wD2KH/kUlK/Z+T/AOV3U/8A2KH/AJFJSv2fk/8Ald1P/wBih/5FJSv2fk/+ Consent to participate: Not applicable as per approval (retrospective study).
ALFD/wAgkpX/ADyyP9Dif+xQ/wDIJKbWB9bMe57h1B2PjMAlrm3CyT4QGhJTe/5ydC/7nU/5ySnS Adobe InDesign 7.5 saved Next generation sequencing technologies thus tantalizingly offer the technology for an ‘exome-wide molecular autopsy’, and potentially allow genetic testing of all major disease-associated genes, as well as genes less frequently involved in any given disease. 2013-05-29T02:39:51+05:30

Sudden Cardiac Death Autopsies Post-mortem findings highly suggestive of causal effect Post-mortem findings of uncertain significance Hypertrophic cardiomyopathy Left ventricular hypertrophy and/or myocardial fibrosis in the absence of myocardial disarray Macroscopic Left ventricular wall thickness ≥15 mm and/or heart weight ≥500 g Microscopic