This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Enzymes, representing the largest and by far most complex group of proteins, play an essential role in all processes of life, including metabolism, gene expression, cell division, the immune system, and others. Please check for further notifications by email. The data contents, the process of data acquisition, data integration and control, the ways to access the data, and visualizations provided by the website are described and discussed. Therefore it is not advisable to rely solely on one source of annotations, but to rather integrate and compare data of several databases and miscellaneous methods. The metabolites can be searched in the ligand search box. The EnzymeDetector provides an extensive collection of genome-wide enzyme function predictions of more than 5000 archaeal and bacterial genomes including their plasmids by aggregating the information of automated annotation databases and manually revised or experimentally described functions. Revisiting the organization of Polycomb-repressed domains: 3D chromatin models from Hi-C compared with super-resolution imaging, VARAdb: a comprehensive variation annotation database for human, ThermoMutDB: a thermodynamic database for missense mutations, CNCDatabase: a database of non-coding cancer drivers, Chemical Biology and Nucleic Acid Chemistry, Gene Regulation, Chromatin and Epigenetics, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.2.3.4, http://www.brenda-enzymes.org/php/search_result.php4?a=250, http://www.brenda-enzymes.org/php/ligand_flatfile.php4?brenda_ligand_id=15923, http://www.brenda-enzymes.org/enzyme_proposal, http://www.brenda-enzymes.org/enzyme_proposal/display_submissions.php, http://www.brenda-enzymes.org/brenda_download/index.php, http://www.brenda-enzymes.org/index.php4?page=information/copy.php4, Receive exclusive offers and updates from Oxford Academic, Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators, Legume information system (LegumeInfo.org): a key component of a set of federated data resources for the legume family, GPCRDB: an information system for G protein-coupled receptors, The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in. For each enzyme, the BRENDA web interface includes an ‘Enzyme View’ which displays all information for a particular enzyme on a single extended page (e.g. Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications. Thirdly the newly designed enzyme summary page (see section ‘The enzyme summary page’ above) lists all pathways for an individual EC class. All enzyme data are linked to a source organism and to a protein sequence if the sequence has been deposited. European Union: [FELICS: Free European Life-Science Information and Computational Services: 021902 (RII3); SLING: Serving Life-science Information for the Next Generation: 226073]. Approximately 3 million data from 83 000 enzymes and 137 000 literature references constitute the manually annotated core. Finn R.D., Coggill P., Eberhardt R.Y., Eddy S.R., Mistry J., Mitchell A.L., Potter S.C., Punta M., Qureshi M., Sangrador-Vegas A.et al. Traditionally chemical compounds are described in manifold ways, with various trivial names, systematic names or abbreviations. In a similar text mining procedure data for diseases that are connected to enzyme malfunction are retrieved and can be found in the connected DRENDA database (Disease Related ENzyme information DAtabase, (9)). Magazines. In these cases the macromolecule is displayed in an abbreviated form with emphasis on the part where the reaction takes place. These classes are not yet approved by the IUBMB and are marked as ‘preliminary BRENDA-supplied EC number’. This information is not shown in the default view but can be viewed by clicking the respective box. Abstract. Several print options on the enzyme summary page: (A) It is possible to print all tables of the page or only those, which are currently visible.